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# Leptospira biflexa serovar Patoc strain Patoc 1 (Paris), Patoc 1 (Paris)

>LEPBI_I3460 Putative cytidine/adenosine deaminase
MDFYESFLKRYSIEVSKYKNEIPSYSEIITKDGNLVSSSFNSVEQTLNPT
KHSEILAIEKALSHVDGRYLSEHILITALEPCILCAGAVVRVKLPEVVYF
LPAKPGEGISSYTTESIYLLNHFPKCTLIPESRIKFEFLSFFKEKR
>LEPBI_I1495 Conserved hypothetical protein with HIT motif
MEDCIFCKIIRGEIPAKKEYETDSIFVFHDITPQAPIHLLIIPKAHIKSM
NEIDSLDPKVIHQIFEVIPELAKKNGIFEKGYRVVNNCGTYGGQTVGHLH
FHLLGGRHLQWPPG
>LEPBI_I0071 Putative S-methyl-5-thioadenosine phosphorylase
MANVVKIGVIGGTGLYSIDGMEILKEIHPDTPWGKPSDTITIGRFKGKEI
AFLPRHGKGHFLNPSEVPARANIAALKQLGVEEIIAFSSVGSLRQEIAPR
DFVIPSQIIDRTKSRHATFFENGMVAHAPFADPFSSGLAKKVEEAAKQIN
LPIHTNKTLICMEGPLFSTRAESHMYRSWGADIINMTVLPEAKLAREAEI
LYQMVCMSTDYDCWKEDEAHVTLEMVLANLSTNADTAKKLLSTLIDLLGK
SDDTSLVGSTKFSLVTAPEKRNPEQINKLKFLFPSYF
>LEPBI_I2667 Putative HAM1-related protein
MQMLLSPFGYEIVTPKILGIPFSPEETESTFVGNSFIKSKELFRLTGFPS
FADDSGISVDALGGEPGVLSARFGGPGLSDKDRALYLLNKLGTNHNRKAH
YSCVVSFVDANHQVSFEGKVEGLIASDYDELGKFGFGYDPIFYYPEFGKR
FSEVPEGEKNKVSHRKKAMELFLEWFQTIQ
>LEPBI_I2860 Putative glutamine amidotransferase, class-I
MRAVIIRFIDCEGPGILEPILREKGYRISYQNAFDSRVQLMPEIHLNFDL
IIMLGGPQSVADPDEQEFFKPYYEIVENVAVLPNKKLIGICLGSQIIARA
LGANVRPGTKGPETGFSDLQILKPEHPIFSGLNGDSLLAFHLHEDIFDIP
VGAEHLLASEFYANQMFSYKNKIFAFQTHLEPTLEMLHVWQNVHKEFIAK
GTGDFSNLKSKQKTMEESAKILFRNIINL
>LEPBI_I1480 Deoxyguanosinetriphosphate triphosphohydrolase-like protein
MKKGRNELLNDEEKILATYAVGSRNFGGRAYEEPEHPYRLPFQRDKDRII
HSHAFKRLEYKTQVFVYSEGDHFRNRLTHTLEVAGISKTISKVLGLNEDL
SESIALAHDLGHSPFGHAGQEALAELMKDIGGFEHNKQSLRVVQKLERRY
PNFPGLNLCEETLLGIMKHGGGYESSNLLEVRRTLGPSLEAMIVDASDEI
TYSAHDLEDGLESGLLQLEEVKGLMIWKRIDESLPSSEKNSKTEMLSISR
SIGRISLNLMVSDLIESIHKILTEYSVNSRESISKLYQKKIKIVQFSEEF
QKEFNELKQFLFQNLYRHSEVSRMSERGKETIYLLFKHFESHPESIPESY
RNREEEDGRMRVICDYIAGMTDRYAIEKLKREGILWFPY
>LEPBI_I1763 Putative hydrolase
MSKSLQSFNPSRRLKVSMSSYEEHSIRKNLFSIGKLGYAKGDRPNVECIL
CGVRDKNEIVPNLTIAETDLSIVSINLFPYNPGHIIIFPKRHIIHYLELT
DEEALDIHRLTQKTMRILEQQWKVQGFNTGYNLGKNSGGSIPHIHEHIVP
RFPNEAGFLDVLSNTRIVIYEPYQMWEDLKKLWVKEEN
>LEPBI_I1151 Putative deaminase
MTRPILLQSASMYQNGKMETKDIVFTGETITKIEDSIPSNNVMFSISLKG
KKLYPGFINSHDHLLASYLPKVGGTEKHLSWLSYDNLYKSSGVFAERQQI
DPEILYYLGAYKNLFAGVTSVFDHIPHFVQNPFRGILPVKLISDYTLAHS
VGNYSLDWGEGPALEYRMAEHANLPFVTHLAEGLDDDSKQSLRYLEKMDA
LGAHSVLVHCLPFGPKEADKIAEKGASVVWCPTSNLHIFGKTTNIKLFLE
RGVNVCLGTESSPSGSNHFLEEIKTAKSIYFGLYGEELSDSDLFKMITEN
PRKAFRMGNPNALMPGLKCDFVVVNDEKKSTELNVSDLHWKHIDLVVIDG
YPIYGSSEFLSLFQEFGLSTEEFVIDGKNKLVAGSPKKLMKQVSESVGYK
KSLAFLPNF
>LEPBI_Ia1510 Putative histidine triad (HIT) protein
MGRMMTCPICQAHKNPSEILFENEFWILRKANQNLDGYLYLEIKGHIESW
NQLTMEQFEAYGRALHKGTELIESSHPEKIYMTAIAERVPHLHVHLIPRF
KGQTPGIEHIAQATGPGFPKPM
>LEPBI_I0154 add1, Adenosine deaminase
MFRIGKKNPNPRWHLYLDSYEKAYGTKIRPSTFFDDYADKNEFAKLYHFL
EKAPFLHFQAKFNLIIALVKFDEPEITEVSHDVVFSNSLEDISYAEYRLM
FGKEEPKESFYSKLMASLEGLKKGEESAKKAGKPIQGKLVMSLHRDLNFE
RHYDWMKNWMEKESVIRDGLVGIDFCHIEEGHPPKDKRLFFQSIQKDNKA
EPNTALSILYHVGESFRDKTPFSAVRWILESAEYGAHRLGHALALGIDSD
YFLGEERTEFVSEAKDQVEHELMYFDEITTYGPFYAKEELEIKRKEYKTK
PDTEILTIPFDETQSQYLHTFQNYAMSKIAKSNAVIECCPSSNLYIGMLE
SHIDHPITRFLQNDLKLTIGSDDPGLFGTTMAEEYHHAHTAGVSDKDLEI
LRSVSLDYRSTKLSGRELD
>LEPBI_I0038 add2, Adenosine deaminase
MYALTKFSILSWNMEVPFSEILSRISVIDRDIAELNRLKSRLPADRPYSP
TIQLTFDKQINTLLNERVSLMELPILHPPLWLLPKEGAEGLEQTTLLKER
KSLLAGDLSVAHPNEQDVINFIREIPKTEVHLHLEACVNKETLKFLYKKN
GIEVTDQEFEDKYNFKDLNGFIQVFFFVQGSVKEASDLGYFIDSLADYLR
SNHIVYCEAFFAPSKFIQNGLDFDEMVEVMVNRIRQIEVKDGISIRLLVD
VSRSFGPENAMNNLKRVLGLKQKEVIGIGLGGAELMGPAKDYAEVFKIAR
ESGLRCVAHSGEDDGPWAIWDAVNLCKAERIGHGTSAIQDPELVRYMKEN
KIPIEICVTSNVFTGKYVRKEQNHPVRYYYDQGLMLCINTDDPDIFNVNL
TYEYFKLYRFLDFSIDELIDLVRQGVLCTFHPEKETLWKSMEEKIDLIKL
KYNLNSEKQVLSV
>LEPBI_I1944 adk, Adenylate kinase (ATP-AMP transphosphorylase)
MKRLIFMGPPGAGKGTQADIIKEKYNIPQISTGDILRAAVKNGTAMGIEA
KKYMDAGDLVPDAVVIGIIRDRLVEADCANGFILDGFPRTVEQAKALSEI
LKELHMELDSVVNLDVPDEELVKRLLGRAIKEGRSDDNEETIKNRLHTYN
TKTLPLIDFYKATGILRQINGLGSMEEITNTILKSI
>LEPBI_II0127 apt, Adenine phosphoribosyltransferase
MMERSAFAGLFLLQDPSLPWFHPFMSIVKSKIRTIPDYPKPGILFRDITS
LLIDPEGFQLTIGMFVERYQNAKLNKIAAIDARGFIPGAALAFQLGVGFV
PIRKKGKLPGNTISESYALEYGVDHVEIHTDAIVPGDKVLIMDDLIATGG
TLEASIKLIQNLKGQIHECSTIINLPDLGGAKRIKDTYGIDVFSICEFEG
H
>LEPBI_I0815 carA, Carbamoyl-phosphate synthase, small chain (Carbamoyl-phosphate synthetase glutamine chain)
MFASLAQFLGMDLMQAFLVLANGTVMKGRSFGANKNSIGEVVFNTSMAGY
QEILTDPSYKGQLVTLTYPMIGNYGINPDDMESDRIQASGLIVKEYVKRP
SNFQSKETLSEFLIRFGVPAIEGIDTRKLTRIIRNSGAMNCGIFISETYE
DSFLETVKNAPSMEGQDLAQIVTCEKPYVFGAHSPSKFKLAVYDFGIKRN
ILRLLDSAGFNVHVFPAKTKAEDLLKEGFDAFFLSNGPGDPAPLDYAIQS
AKTIMDAKKPLFGICLGHQIIGLALGKKTAKLKFGHRGGNHPVRNEETGK
IEITSQNHGFHVLGESSEDMPITRLNLFDNTVAGLKTKGLPVMAVQYHPE
ACPGPHDSAYHFQEFYTMVETSKG
>LEPBI_I1281 carB, Carbamoyl-phosphate synthase large chain (Carbamoyl-phosphate synthetase ammonia chain)
MPQRNDLKSILIIGSGPIVIGQACEFDYSGTQATKALREKGIRVILVNSN
PATIMTDPDLADATYIEPLTVPVLEKIIKKEKPDAILPTVGGQTALNLAL
ALHREGVLEKYNVELIGAKVDAIRKAEDRELFKLAMEKLGIRVAKSFMVS
DMEAARKAKDEIGFPIIIRPAFTLGGTGGGTCYEESEFEEIAQKGLSASP
ISQILVEESVMGWKEFELEVMRDLNDNVVIICSIENLDPMGVHTGDSITV
APQQTLSDKEYQRLRDMSIDIIREIGVETGGSNIQFAVNPENGDVIVIEM
NPRVSRSSALASKATGFPIAKIAALLSIGYTLDEIRNDITRVTPASFEPS
IDYVVTKIPRFAFEKFPGSDNTLGVQMKAVGEAMAIGRNFKESFQKALRS
LETDRFGFGSDGYLKELMEWETVPKEQRHEWLTARVKRPTDKRIFYVKMA
FDFGMSVEEIHEICKIDPWFLYQFEELFQLENKYRKDGNTIIEEMKQAGF
SNRQLAFLSKEEQILAQVRSGAAIEITKAKVEKTLREEEEKIESYLEEKN
IHPVYKRIDTCAGEFEAFTPYMYSTYDEEDESDVTSKKKVMILGGGPNRI
GQGIEFDYCCCHASFSLQEAGVESIMVNSNPETVSTDYDTSDRLYFEPLS
LEDVMAIFKKERPDGVIVQLGGQTPLKLAKSLEKRGVPILGTSPDSIDRA
EDRKRFAEVLEKLNLKSPENGIASSKDKAREIARKIGYPVLVRPSYVLGG
RAMLIVNEETELDKYMEEAEEVSEDRPLLVDSFLQDATEVDVDALCDGKD
VFIAGVMEHIEEAGIHSGDSACVLPPQSISQRMIQEIEEATLRLALELDV
KGLINVQYAIKDETLYVLEVNPRASRTVPFVAKSIGIPIVKIAVRLMLGE
SLASFKLGKRFSAPMITVKEAVLPFSKFPGVDTILGPEMRSTGEVMGVAA
TKGEAFVKAQIMAGEEPPKHGTVFVTINDKTKKELLESVRSLSNLGYNII
ATEGTHKFLSDNGILSSKINKIYDGYFPNVIDYIKEKKIHLIINTPLSRV
TRENAFTIRQAAIKYKVPCLTTAQAAKALIHGLVEMKDKGFSVNSLQEIH
KKK
>LEPBI_I2596 cmk, Cytidylate kinase
MSLQSIENVIAIDGPAGSGKSTLARMIAHKLGFHYLDSGAFYRALTFALL
EKFKETKEDESKFPFYTEKLADATLLEKDESEFGFSVAAIPVHCELSSTG
ENLMFLGERDISREIRDPEITKKIRYIAPRRAFREILNRHIREFAKTHRL
VMDGRDIGTEVFPKSKFKFFLTASVEVRAKRRYDELVTKGFKADLNHIKE
EIVARDESDTTRTVAPLKQASDAILIDTSTLDTETVLNTILSKVSPSGQI
>LEPBI_I3246 dcd, Deoxycytidine triphosphate deaminase (dCTP deaminase)
MILTGKEILKRLGSDIKIEPYDEKLLNPNSYNLRLHEDLLVYSEFPLDMK
KPNPVRTLKIPEEGLLLEPGNLYLGRTIEFTETHNLVPMLEGRSSIGRLG
MFVHITAGFGDVGFKGFWTLEIQVTHPLRVYSGVQICQIFYHTVEGEISE
YKSGKYQANQGIQPSLLYKDFEKK
>LEPBI_I1531 dut, Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase; dUTP pyrophosphatase)
MLEPENYLQIQILKEGAVLPEYKTPGAAGMDLSACLSENLLLPKGEVVLV
PTGLAMAIPEGYEGQIRPRSGFSTKHRIIMPNSPGTIDSDYRGEILIPLL
NLSGEDFVLKPGTRVAQLVIQAVSQLPIQVVTGLDATQRGTGGFGSTGK
>LEPBI_I0951 gmk, Guanylate kinase
MKAVPNLYIISSVAGGGKSTIIQALLKENPEFYFSISCTTRDPRPGDEEG
KTYYFLTIPEFQKKIADGEFYEWAEVHGNYYGTPKAPILDAIKEHRVALM
DLDVQGAKSVKQLRPESVTIFIEPPSREIWIERLIRRGTDSKTSIEKRIE
NGIIELDEAPSFDYVVINDRLEDAITEVKAILCGTKS
>LEPBI_I1615 guaA, GMP synthetase [glutamine-hydrolyzing] (Glutamine amidotransferase; GMP synthetase)
MTSDKKIAVVDFGGQYAHLIASRIRRLGAYTEILSNEEPLSRYESYAGII
LSGGPSSVYETGAPLLPAGFFDTSVPVLGICYGHQLMMKTLGGEVVSAST
KEYGPAILEIENPNSPLSQSLSLKTKVWMSHGDEVVRLPNDFQVIAKSDH
CRYAFVSHPSKNLFGIQFHPEVTHSEEGEILLKNFVELCGASGTWSIQHF
LDEQIQSLQKKVPEGKNVFLLVSGGVDSSVAYLLLAKALGKDRVKGLLVD
TGFMRKNEVKDLMDNLHHVGFDLTIWDESEVFYKSLQNEFEPEKKRRIVG
DLFLEAQGKATTSLGLDAEHWLLGQGTIYPDTIESGGTKHSHKIKTHHNR
VPQIEALIREGKIVEPIADLYKDEVRELGRTLGLPERWIERHPFPGPGLV
VRMIASPRTSPPNIDFSIWKEKIPKAEIQILPILSVGVQGDQRSYAHCAV
LSDFTSDWKELDNLSVEITNTKKEINRVVLAPGITHFEKDFFYTKLTLDK
THADILRDADAIVNQILYDESIHNQIWQMPVVLVPVGLRENSYGVVLRPV
ESTEAMTANFYQMNRNILARITKELLELPQISLVMYDLTHKPPGTIEWE
>LEPBI_I1272 guaB, Inosine-5'-monophosphate dehydrogenase
MSNHPLPGTELLDGVSGQELFSVNMGLTYRDFLVLPGYIDFNPSDVELET
KLSKNISLKRPLMSSPMDTVTESEMAIAQALMGGIGIIHYNNTIEEQVDL
VRKVKRFENGFIKDPILLSPEHTVADLDAVKEKYGFSGIPITENGTANSK
LVGIVTNRDVDFEKDRNIKLGKVMTTELITANVGISLLEANDILRTSKKG
KLPIVDKQGKLVALICRSDLKKNKEFPQSSKDDQKRLRVGAALSTLPESR
DRMAALAGVGVDAIIIDSAQGNSSYQIEMIQWIKSNFPNIDVIGGNVVTK
AQAANLIGAGADGLRIGMGPGSICITQDTMAVGRAQATAVFKTAEYAQAH
GVPVIADGGISNIGDIANALAIGASMCMMGSMFAGTKEAPGEYFYENGIR
LKKYRGMASLEAMSKGGDKRYFSESQKIKVAQGVSGYVVDKGSVLNLIPY
LVQGLRQSFQDMGYRNIPDLHKALREGKLRFERRTESAQAQGSVHGLYSY
TKPSMRAE
>LEPBI_I3157 hpt, Hypoxanthine phosphoribosyltransferase (HPRT)
MKPLYSEERIHQRVEELAREISRDFLSKDLVVIGILNGGFIFTADLCRSI
AIPHEVDFMGASSYGDGTSSGDFKITKELKKSIQNKSVLLVEDIVDTGKT
LEYLLLEVQKQNPKDLKVAALFWKQKKANPHIIVDYPGFIIEDDFLVGYG
LDFQGKYRNLPYVAKLEGTD
>LEPBI_I0084 ndk, Nucleoside diphosphate kinase
MERTFIMLKPDAVKNKHIGDILQRIEKEGFKILGMKFLKLSLEDAKQFYA
VHAARPFYNDLCTYMASGPIVACALERDNAVAHWRDVIGATDPKEAKAGT
IRALFAESKEANAVHGSDSVANALQEIAFFFKGYELN
>LEPBI_I1686 nrdA, Ribonucleoside-diphosphate reductase alpha subunit (Ribonucleotide reductase)
MKIERHFTKGNKGLYPNLTWVRKDSKITNTDGSVVFEANGVEVPDFWSQV
ATDILAQKYFRRKGVPKYLKKVSEKGIPEWLQRSVPDDEKLAALNPEDRY
VGELDSKQVFHRLAGCWTYWGYKYGYFTEEDSARVFYEEVIFMLASQMAA
PNSPQWFNTGLHWAYGIDGKSQGHYYVDPKSGKLVRSASSYEHPQPHACF
IQSVDDDLVNEGGIMDLWVREARLFKYGSGTGTNFSNLRAANESLSGGGK
SSGLMSFLKIGDRAAGAIKSGGTTRRAAKMVCLDMDHPDIEEFIDWKVQE
EKKVASLVTGSILNNRLLNDIMSACASAKQSLGEEKAYDPAANVELKKAI
QKARKAFVPDNYIKRVIDLSKQGYKDLLFEELTTDWQSEAYNTVSGQNSN
NSVRITNEFMEAVEKDLPFHLINRTEKENARKDGREPKAAKTLRARDLWE
RIANAAWNSADPGTQYHSTINEWHTCPEDGAINASNPCSEYMFLDNTACN
LASANLVKFLKEDGTFDVEGYRYLNKIWTIILEISVLMAQFPSKEIAELS
YKFRTLGLGYANLGSLLMIMGIPYDSQEAMAVTGAISSIMHMTAYATSAE
MAKELGPFAGYEKNKNHMLRVIRNHRRAAYNAPKEEYEGLTITPVGINPS
FLPSYLLEAAKEDSDRALELGEQYGYRNAQVTVIAPTGTIGLVMDCDTTG
IEPDFALVKYKKLAGGGYFKIINQSVPAALKKLGYSQAEQDAIVNYCKGH
ATFNGAPGVNTARLKEKGFTEDVLEKLEKQLPFVFDIQFAFNKFTLGEDF
LAKTLGIDPSLYNSMGFNLLETLGFSADEITQANDYVCGTMTIENAPFIK
EKDLPVFDCANKCGKYGKRFLSYQSHIRIMAAAQPFISGAISKTINLPEE
ATIEDVKNAYLMSWKVMIKANALYRDGSKLSQPLNSVFQLLSAVGEDEEE
LQTSSAPKTVTEVAEKLVYKYISERRKLPHRRAGYTQKAMVGGHKVYLRT
GEYEDGQLGEIFIDMHKEGAAFRSLMNAFAIAVSLGLQHGVPLEEFVEAF
TFFKFEPNGMVSGNPHIKMSTSVIDYIFRELAITYLGRYDLAQVSPDDLR
TDEVGRKAEPAKDNVGKLESSGPRTPLPVNAISMKSVLEDKQEVVVAVAG
QSTQPTQAQSAAATLKIIAEARTKGYTGDSCTECGSFQMVRNGACLKCIS
CGSTTGCS
>LEPBI_I0447 ppx, Exopolyphosphatase (ExopolyPase; Metaphosphatase)
MLPFSQILRKPNQAFRSEKILAAIDLGTNSFHIVVVKLRPDGTLEYLTKE
KESVRLGSGSSDYAVIKDDAIERGIACLKRFKTLADSYKAEIRAVATSAL
REAENRQVFLDRAEKETSIQIQVISGNEEARLIYLGILQGLPVFDKRILL
IDIGGGSTELLIGEKGEILFSTSMKLGAIRLTEKYLKKDPLSATDLQKCR
IHIESVLSAFLPQIERLKPFLVVGSSGTITSVTSMVLEKKGEKRERLNGT
EITIDLFKEIRKQVLDAESIKKRLKIPGLDAKRGDIIVGGVLVLDEVLQR
IKAPSFTVSDFALREGIVYDTIESWYRHTDTSLPRLDNIRDKAIKTVANL
YPQGKKHAEAVTKLTLQLFDDLTNLHGLGNLERDYLETACYLHQVGLCIS
HHNYHKHSYYIIRNSEAMVGFSNAEIEIIALLARYHRKGGPKGKHEEFKN
LRPEDQLLVKKLASFLRIGDGLDRSEKSIIDRLDAVVEKGKVSCRLYFKK
NEDPNLEIWSVSEKKDLFEDTFSTTLEFHLHPI
>LEPBI_I0236 prs, Ribose-phosphate pyrophosphokinase (Phosphoribosyl pyrophosphate synthetase)
MNPSEVVVFSGNANRPLAEEICKNLKIPNGQISVKRFSDGESSVKIEENV
RGRDVFVVQSISYPANDSLMELLLIIDAARRASARRITAVIPYYGYGRQD
RKVEPRVPISARMVADLIETVGPDRVLTMDLHADQIQGFFRIPVDHLYFS
PVLAEYINSLGMDDLVIVSPDSGGAERARNFGKKVNGSLAIIDKRRPKAN
ESVVMHVIGDIKDKNCLLLDDMIDTGGTIAKAATALYENGAKSVLCCASH
GVLSGEAPSKLNEAKFNPIVLSNSIVIPESKKINHLKTLSIAPLFAKAIE
RIHNEESISSLFS
>LEPBI_I1934 purA, Adenylosuccinate synthetase
MPANLVVGAQWGDEGKAKVIDYLSKDTDIIVRYQGGANAGHTVVVGGKKY
IFHLVPSGIIYDNTTCVIGNGVVLDPEYFLKECADLETHGFRVKDKVLIS
DSCHILLPYHRLIDEAREAGSSPERKIGTTKKGIGMCYADKMLRNGVRAG
DLLDKENLKRKLNHILEVKNQELVKYYDLEPVNPNEMYDFLLDFADKMGK
NIINTVYYLNSELEKGKRVLLEGAQGTGLDIDFGTYPYVTSSNPTTGGAL
AGSGVSFRYLKDVIGITKAYATRVGEGPFPSEILGEAGDVLRKLGGEYGS
TTGRPRRCGWFDVQMIKHAVTVNGINSLVLTKIDVLSHYETIPVVVGYEY
KGKKLDFFPSQGLEDVKPLFAEYKGWKDDISGINSFAKLPPLCQSYIKSL
QELVNTKIGIVSTGPDRDHTIIMD
>LEPBI_I0049 purB, Adenylosuccinate lyase
MIDRYSHPEISAIWELENKFKIWTDIEIYACEARANRGEVPKEDLETIKQ
KAKFNVDEILEIESKVHHDVIAYLTNLNSYIGPAGRHVHFGLTSSDVGDT
ALCVQMVQAMDLLIQRTETLLETTKQKAKEYKDLPCIGRSHGIHAEPMTL
GLKFALFFAEMTRNLERMKDAREQVAVGKLSGAVGTYSNIDLEIEEYVLN
KLGLKVDPIATQVISRDRHAFYMSVLGVVAASLDRMATEIRLLQKTEGRE
VEEPFAKGQKGSSAMPHKRNPVVCERISGISRVIRSNVNVGLQNVGLWHE
RDISHSSAERIVLPDSTIALDYILEKMNFVLKGLHVYPDATERTLNVTRG
LIFSQKVLLWLIEKGGITREDAYLIVQENAMAVWADQSKNLRDLLKQDPR
CSSILKDSDLDEIFQIKPYLERIPLIFKRLGIID
>LEPBI_I1925 purC, Phosphoribosylaminoimidazole-succinocarboxamide synthase (SAICAR synthetase)
MIPNPHYKGKVRDVYDLGDKLLLVATDRISAFDVVFSEPVEDKGKILTRI
STNWFRYFSNIPNHLVTDDPNLFPKPYQNEPSLLGRSVLVKKAKRIDFEC
VVRGYLTGSAWKEYLQSGTIAETPYPKGIQESFQFPSPIFTPARKNDSGH
DENVSEETMEREVGSVLFQKVKQISLRLYEEAHDLMAKQGILLCDTKFEF
GLIGDEPILIDEILTPDSSRYWDKSTYSLGKTPASFDKQILRNWLETTPW
DKNPPPPQLPESLIQELRKKYLELEEKINLCLSQK
>LEPBI_I0251 purD, Phosphoribosylamine--glycine ligase
MDNQYKVLLLGSGGREHALADAISKSNVLESLKVYPGNGGFSEDVLLKAD
EISITDKSKFIEYIKSSQTNLVVVGPEDPLVNGIADWCEEIGVPCFGPSA
YCAQVEGSKHFAKEMMKRAKVPTASFAVFTDHESAWSFAQKEMLPLVVKA
DGLAAGKGVTVAFEMKDVKRALDEIFLESKFGQSGYKVVLESFLEGEESS
LFVITDGERYMCLPAAQDHKRAYDGDIGPNTGGMGAYAPAPIVTEAVLEK
VKSRIIEPMLDDFKRSGHPYKGLLYVGLMITKEGEPNVVEFNCRFGDPET
QCVLRLLDEDILPIFYASAIGNLPVRNLKLKQGSSAVVVLAAKGYPDSPE
KGMVLEIPPNEGNVVVYHAGTKRDNSSLLANGGRILGITSFGKTLKDAID
ECYTFLSTIKAPSTFYRKDIGRRAL
>LEPBI_I1754 purE, Phosphoribosylaminoimidazole carboxylase catalytic subunit (AIR carboxylase; AIRC)
MTNPLPKVAVIMGSYSDWDTMKEACEILTEFGVPFEKEIVSAHRSPDRMF
QFAKNAKNNGFGVIIAGAGGAAHLPGMTASLTTLPVLGVPVLSKALNGMD
SLLSIVQMPKGVPVATLAIGTSGAANAGLLAVRILSLLDSSLSKKLEDYA
DQNREQALSKNDQLV
>LEPBI_I0173 purF, Amidophosphoribosyltransferase (Glutamine phosphoribosylpyrophosphate amidotransferase)
MILQSDKPKEECAIYGIYNSKEAANFTYLGLYSMQHRGQESSGIVSTDGS
HLYRYANMGLVANIFTQPKIKELIGDAAIGHNRYSTTGASFLRNAQPVRV
ESHLGPVALAHNGNLVNSWDIRNRLERDGSIFQTTIDSEVIVHLMAKSHK
TDLLEALCESLAQVRGAYSLLVLTPRYLIAVRDPNGFRPLVMGKRSDGAI
VFASETCAFDITDTEYVRDVEPGEMVVIDHTGMRSLYPFPKAKPSLCIFE
YIYFARPDSYIFEESVYKVRKSLGRQLARVMPVEADVVIPVPDSANIAAL
GYSEESGIPYQSGLVRSHYIGRTFIEPDQKIRDFGAKIKYNVVKEVVNGK
RVVIIDDSVMRGTTSRKIIKMIRNAGAKEIHFRVSAPPTVAPCYYGIDIP
THKELIASTHSIEEIQKYLRVDSLAYLTLDRMHKAVEGHKGGGFCDACFT
SNYPVEFQDHAGNQKSLFTEYATEE
>LEPBI_I1469 purH, Bifunctional protein: phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
MIQIKRALVSVSDKTGITEICSFLTKHGVEILSTGGTYDALSKAGIAVKK
VDEFTGFPEILHGRVKTLHPKIHGGLLGDTTNPDHVKQMESNGIVPITLV
IVNLYPFVKTVMKPDVTLEDAIENIDIGGPSMLRSAAKNHKNVVVLTDPK
DYESFQNEFTTNNGKISRETAFGYAAKVFSETASYDSAISSYFNKRLGIK
YPDKITFAFNKKQKLRYGENPHQDAAFYEPLFLKSQFEALQGKELSFNNM
LDFDAAFHVASLLPKNAVSIVKHLNPCGIAFGETVLESFELARKTDPISA
FGGIIGIHGRVEKESAEEITKNFVEGVIAESFSNEALEIFAKKPNIRLIP
IAKFDEALDELDLRSLHHGLLIQNRDYDLITKDKLKIVSKKQPTEDDLEG
LMFAWNCVKFIKSNAIVYTDQNSTLGIGAGQMSRVDSVELGAMKAQKVGL
SVVGSYVGSDAFFPFRDGIDAIAKVGAKAIIQPGGSIRDEEVIQAADEHG
LIMVFTGMRHFRH
>LEPBI_I1755 purK, Phosphoribosylaminoimidazole carboxylase ATPase subunit (AIR carboxylase; AIRC)
MMKIGVLGSGQLGQMMCLEAIPLGHDFYCYSPDLNSPSEKLGAKATIASY
DSIQQLESFLQTIDVLSFEFENIPKPTLEFLKNQKLIAIFPPPQALIIAQ
DRFLEKNHFRKLGFETAEFFHLTKASSKFEISIPFPWIIKTLRFGYDGKG
QVKVNHQSEYESFLQSAFLKDESEYLIEEVIPFQKEISILLTRFQNGDIV
CYGAVENEHKNHILDLSIFPARIPVGLNLEAIEMASKLAESLHYVGTMGV
EFFLKNNQLYLNEFAPRPHNTGHFTQDCQSFSQFYLHVQAITGNTPPTDV
RPKPTLMKNILGNSFEESLEIASELQKDDRYRLHLYAKEEAKPGRKMGHL
NFKGSLEEVNPLFHDL
>LEPBI_I2154 purL, Phosphoribosylformylglycinamidine synthase II (FGAM synthase II)
MEKEKVSLADAKEHGLTETEFVEIQKILGRIPNSTELGIFSAMWSEHCSY
KNSILKLKTLPTKSDKLLAGAGEENAGAMDIGDGLAVVFKIESHNHPTAV
EPYQGAATGVGGIMRDIFTMGARPITSLNSLRFGDPKEPRNKYLLTRAVK
GIGDYGNSLGIAVGGGELFLHPTFTKNPLVNAMTVGIAKHDEMASASTKG
KVGNKVYIVGATTGRDGIHGASFASKDLTKESEEKRSAVQVGDPFMEKLL
MEASLEAIQKKLLVGIQDMGAAGISCATSEMSAKGKTGMDVDLDKVPLRE
ADMNAYEIMLSESQERMLVIPEVGKEGELVSIFHKWGLNAVEIGTVTADG
ILRIRKNGTLKAEIPAESLVLGGGAPRYVREEKRPTYLDEVVKFDPNKIP
DLKPDTVPQTLNSLLSSLNISSRRPLYEQYDTEVGLVKVVEPGEDGGLVR
IPGTKKGIAVATDCNSRYTYLNPYEGAQIAVCESARNVAATGAEPYGVTN
NLNFGNPYIPENYYVFSECVRGLGDACRFLGLPVTGGNVSFYNESPEGPV
FPTPTIGMVGVIDDVAKGLRTYPRTKEDVKYALVGNFQPTISASEYLYRS
QGLDTGAIPNISLEKEKQTMDALIECRKNGLLTSAKDLSLGGLLVALAKI
VIAGKKGVEVNLNELQTKVPRLDALCFGETGASFIVSFLPNDETKVRESF
TSKGLSVYTLGSSSAKASLSVKGDGFHWEWTTKSLEVEFESGLKSYFE
>LEPBI_I0914 purM, Phosphoribosylaminoimidazole synthetase
MSDQNKITYKDAGVDTEKGQEFVKRIKANVASTHNKNVLGGLGGFAACYD
VSFLKSYQEPILLSGTDGVGTKLQIARQLGIHNTVGIDLVAMCVNDILVN
GGKPIFFQDYIACGKLHLPTMEAIVSGIVKGCSLADCSLVGGETAEHPGV
MPDDEYDLAGFVVGVVEKGKMIDGKTISPGDTIIGLKSSGPHSNGFSLIR
KLLLKDGKLPTSQEQIDFIKDHIFVPTNIYVKSILSLIDKISIKGMVHIT
GGGFYENIPRVLPEGVGAEIFSLPESYVFSKLEKDHSLDRNDMYGTFNMG
IGYILVVDSSLVDATMNELHVLGEDSFVIGKTNDSGKISITL
>LEPBI_I1470 purN, Phosphoribosylglycinamide formyltransferase
MGKTKRVVFLASGRGSNFSAAVESIQKKKLKLDILALVSDNPEAKALTIA
KNFGISTKVIPYGSYQSKSDYHRDLLRQVEAYDPDLIVACGYMRILKPEF
VQRFKNQIINVHPSLLPAFPGLDSQKQALDYGVKVAGCTVHFVWEGVDTG
PIILQKAIAIRPEWTEKELSLAILKEEHIILPLAIQLFCEDKLKIKERKV
EILK
>LEPBI_I1923 purQ, Phosphoribosylformylglycinamidine synthase I (FGAM synthase I)
MKVRVVTFPGSNCDKDVGSVLQESFQAEVIYTWYKESFEDVPDLVVLPGG
FSFGDYLRCGAMAKFSPSMESVVKYANKGGKVLGVCNGFQILTESGLLPG
ALLHNRTLKYICKDVELVPVKENSFAKKMEGTLSIPIAHGEGAYFADPET
LERLEKNGQVVFRYRENPNGSLHDIAGICNERGNVLGMMPHPERAMNPYT
GKMDGKQILEALLKN
>LEPBI_I1924 purS, Phosphorybosylformylglycinamidine synthase PurS component
MFVAKINVTLKESVLDPQGQTVLRTLHDQGKLQIQDLRVGKYIEIKLNAS
SQKEAEEIAKGICESVLVNQVIETYKLVVESQ
>LEPBI_I2735 purT, phosphoribosylglycinamide formyltransferase 2
MIGTPFTKHATKLLLLGSGELGKEVAIEANRLGVHVIAVDRYPNAPAMLV
AQESRVINMLDPKELEATIRELKPDFVVPEIEAIHTETLVTLEKDGFKII
PSAKAVNLTMNREGIRNFVANELGLITSQFLFADTIEDFTNAVHTIGFPC
VVKPIMSSSGKGQSLVKTEADIIKAWEYGQTGGRTGKGKMIIEEFIPFDF
EITLLTIRHIDGTSFLPPIGHRQVNGDYVESWMPQPMSDLALTSAKNIAE
TVTTGLGGFGIFGVELFVKGDEVYFSEVSPRPHDTGLVTLISQNVSEFSL
HVRALLGLPIPELIFQTPAASSAILLEGNTKSPEYVGLKEALAIKGVDIR
IFGKPEVEGKRRMGVSLALGNTIEEAKEKANRGRDHIQLKT
>LEPBI_I1026 pyrB, Aspartate carbamoyltransferase, catalytic subunit (Aspartate transcarbamylase; ATCase)
MYAYSHKNILDTLQFSKDDLNYLITKTNRMNALHESGKAFGILHGKLLAS
LFFEASTRTRMSFEAAMERLGGRLISTVGFQFSSISKGETLYDTMKMIEA
YCDIAVIRHPVEGSSRIAAGAVNIPVINAGDGAGQHPTQALLDLYTIVSE
KGKIDGLNIAFIGDLKYGRTIHSLINLLRHYPVHLYLISPEELRLPEKYK
KNLEGFPMTWEETTDIKAIWDADVAYVTRIQEERFPDHREYEKLKDIYKV
NKELVLASKKDTTILHPLPRVNELSTDVDDLPNAAYFRQAKYGVVVRMAL
LCLSLGVNFD
>LEPBI_I0308 pyrC, Dihydroorotase (Carbamoylaspartic dehydras; DHOase)
METIAGKIVTHEKEFLGSIEFDPTTGLITKVKEGIEPKSRQFSEDCVIFP
GFGDIHIHAREDVTGKHTYKEDFLSASAAAINGGVIHVADMPNNPVPPID
DATYAAKQALTEKAPIHITLYAGIGPHTKPLSKKVPYKVFMGPSIGELFF
HDNPSLEEVIQHYEGQDVSFHCEDPEILIANKDQPTHETRRPKEAETVAT
DFALYLIEKYNLKGKLCHYSTKDGLSKIIAAKKRGVKVTCEVTPTHLMFD
TDMLTETNHKWFQMNPPLRGRADREAMVKGILDGHIDYLATDHAPHSIEE
KQKGTSGISQLDTYGLFVTYMILNLNIPMTLIAKICSKNPGEFVAPYLPK
QFGKGVGVINEGYAANFSILNLKKPVEFKKSMIKSKSGWSPFEGFQFPGS
IEAVYYLGKEIHAK
>LEPBI_I0092 pyrD, Dihydroorotate dehydrogenase (Dihydroorotate oxydase)
MFYHQLIKPILFHLDPESAHHLVATFLSLSKKIPFFHKTLSAIFQFSSKR
LEQTIQGIHFPNPVGLAAGFDKTTELFPTMIHMGFGFIEIGTITAKAQPG
NEKPRLFRYPKVKALINRMGFNNPGADQAEINLKNQQKLGVRGINAGKSK
VTALEDAVGDYVYTLKKLVPFGDYAVINISSPNTPGLRSLQTKQSLIDLI
QGIQKEFQNSFPIPLYLKFAPDLTEEELIENLKVCLEYKISGVILTNTTL
DKQSLGELNPEEGGLSGGPLFQKSLRFVSLAYQTLQGKIPIIGVGGIDSG
EKALQMMEMGANLIQIYTGYIYEGPFLPYQICSYLDKVVKDRGYQTISEL
VGSGNSK
>LEPBI_I2428 pyrE, Orotate phosphoribosyltransferase (OPRT; OPRTase)
MSHSHRDALFQWMKTYVYRHSETPFRLASGLESQHYFNCKEITLHPERLS
ILAECFIEEIIPKLNIEFQAVGGLTLGADPIAYAISLGYQKRGKNVFPLV
VRKESKGHGTGQQIEGFWKDIKTCLVVDDVITTGGSTLKAVKVLREVGIN
VTKGICILDREEGGSENLQTENVTMTSIFAKSEFF
>LEPBI_II0110 pyrF, Orotidine-5'-monophosphate decarboxylase
MTSFLSKFRNRRDGLRSQLCIGIDPELEKLPKVCLDSKSPLVHFSETIVR
YTHPYAVAWKPNIAFFERLGAEGYFALEHMVHLMKEVSPEVPIVMDAKRG
DLANTAKEYAKYFFQTLKVDALTVNPYMGRDSLTPYLDLGGYLFVLGLTS
NPSSSDFQKLKTKTNDLYLYEEVSDQMASLSEVYPGQVGLVVGGTHPSEI
QSLRKRHPDLCFLIPGFGAQGGDLESIIHASGKEALINSSRGITLSSLAE
NYGEVSKKKSEEVHLRMNHLFP
>LEPBI_I1645 pyrG, CTP synthase (UTP--ammonia ligase; CTP synthetase)
MSKTRYIFITGGVSSSLGKGVTVAALGCLLEARGYTVSLQKMDPYINIDP
GTMSPYQHGEVYVTEDGAETDLDLGYYERFTKSKFSRKNSVSTGQIYHAV
IERERKGDYLGRTVQVVPHITNEIRSRIYNLTRDQETDFVIVEIGGTVGD
IESIPFLEAIRQMRYEHGNQQVLFLHLTLVPTITAAGEAKTKPTQHSVKE
LLALGIQPDVLICRINKPMSKEMKNKISLFCNVKEQNVISAVDITTSIYE
IPLMYREDKLDEVVLNALGMDLRKLNFSQWENMVKKIRNTKKTVKVALIG
KYISLQDAYRSVYESLAHGGIANDVEVSVVKINPEDIDSKNIKELLKGVH
GVLVPGGFGERGIEGKIAAIQYARTKNIPFFGICLGMQCAVIEFARNVLG
FKDANSTEFKPNVQYPVISMIEEQKEIERMGGTMRLGAYPCLVKKGSLAH
SEYKSDRISERHRHRFEFTLRYKDDFEKKGMNLTGFSPDGSLAEIVEIPN
HPWFIGVQFHPEFQSKPTDPHPLFAGFIKAASKLAKKTED
>LEPBI_I2615 pyrH, Uridylate kinase
MGTSPRFKRILIKISGEALAGEGELGIDTNKTFSLAGQIKEVHDLGLEVA
VVVGGGNMIRGETLAKSGMDRATADYMGMLGTIMNGLALQDACEKQGMFT
RVLSAIEMKSVAEPYIRRRAVRHLEKNRVIIFAGGTGNPYFTTDTTASLR
AVEVGCEVILKATKVDGVYTADPKKDPSAKRYLQVSFMESIKHRLKVMDS
TALSLCMDNNMPIIVFDIFKAGNLRKLIDGEPIGTLISNSEEVILDGR
>LEPBI_I3300 thyX, Thymidylate synthase ThyX (TS; TSase)
MQQSDFESISRVSVPELDSILGKPFPILDDGFVRLVDYMGSDESIVQAAR
VSYGKGTKKVNEDRGLIRYLMRHRHSTPFEMCELKLHVRVPMDTWRQWIR
HRMANVNEYSTRYSVAIDSAQTTLPGEWRVQSVGNKQGSDGYLESSKGDH
LTKRETEFQKFANDIYNERLEMGVAREQARKDLPLATYTEAYWKIDLHNL
LHFLALRMDDHAQLEIRLFAKTIGEQIVQKWVPHTWEAFVDYRLSALHLT
KYDTEIIAALNVSGKEGAIKKAIQLGMLDDQGTTAKKSREREELEYKLSQ
LGFSIPW
>LEPBI_I1268 tmk, Thymidylate kinase (dTMP kinase)
MPFKSQFFVFEGIDGSGKTTVSKKVSEILSTKSISNLWHREPTDSIHGQK
IREFLQGKIKLTPDEQLKLFLLDREFSVNETILPTLKSDTCLVQDRYYFS
TAAYQGRDEEHAADILYMNEDKGFPEPNRVYFLDLSPEEALERRNTRGGN
KEAFDDEKEQTRIYQNYLAILPESTIFVDATADLEEVVNFCVEDILLSLS
LKT